Yes. I used REI-bought gear that I've got for backpacking--
* a Mountainsmith 2-man backpacking tent (actually a nice amount of room for me and my stuff--whatever you get, use a thin tarp or nylon footprint below to save the floor and get something with aluminum poles)
* a Therm-a-rest sleeping pad--luxurious after long days in the saddle. Speaking of saddle, a sheepskin seat pad and a gel insert in the seat (Sargent did mine) are really good to have.
* a REI Sub-Kilo down sleeping bag--size of a loaf of bread, 750 fill power down. Always use a sleeping bag liner (get a silk one from eBay like I did, or cut and sew a thrift-store sheet). I always find that I sleep cold for the first 2-3 days and acclimate by the 4th.
*I didn't bring a camp stove, preferring instead to get apples, jerky, crackers, energy bars, etc. at grocery stores, supplemented with 1 restaurant meal a day. If you do, REI carries some great tiny backpacking stoves. I recommend the multi-fuel stoves with the separate fuel bottle, like the MSR Whisperlite. The stove will burn gasoline, which means you have a spare small fuel bottle tucked away--often good.
*Many car parts places will let you buy oil and a cheap pan and funnel and change oil in their back lot.
*Carry a decent toolkit, a tire patch and pump kit, and raingear (Frogg Toggs are decent and light, XL rubber dish gloves work for hands).
*Do all your scheduled maintenance before the trip, make sure your brake pads are fresh, your chain is new, etc. and keep your tire pressure checked daily and your chain lubed daily as well. Bicycle shops sell squeeze bottles of clear teflon chain lube that works fine for moto chains.
*Be really careful about fatigue. Pace yourself, don't pack in too many miles, and get enough food, water, and sleep.
*Get an annual National Parks pass (80 or so) and use it for all it's worth.
* Hard bags are awesome--waterproof and lockable. Soft bags are cheaper and very versatile, but you'll want to use some Snider's Paintguard or contact paper to protect the bike's paint where the bags touch. Check bungees and straps and bottoms of soft bags daily--they can fray, break, melt, burn through.
* Also, be sure to get off the bike sometimes and go for a hike, see a show, browse a bookstore, swim in the creek, whatever you like to do. Make it a well-rounded experience. I found that I got rather lonely after 5 days or so, and made sure to visit friends and relatives when possible, and had a book of postcard stamps to send postcards in the meanwhile. Pay lots of attention to your emotional and physical state--you're all you've got out on the road.
* Bring a GPS and/or a state-by-state atlas, but talk to locals and other bikers you meet and get their recommendations as well. Some of the finest roads I found on the trip were ones I'd never heard of, but was told about by other riders or folks I met along the way.