On my built TRX450R for example... (my actual numbers may be a bit off, I am getting old)
Stock to Piped required going from a 150 to 205 Main and 48 to 50 Pilot
Piped and added Stage 2 Cam required going from 205 to 180 and keeping 50
Piped, stage 2 Cam and adding 13.5 Piston required 180 to 175 and 50 back to 48.
Piped, stage 2 Cam, 13.5 Piston and Ported head required 175 and back to the 50 Pilot.
Full built motor (14.5 piston, Dangerously aggressive Cam, ported head, Stroked, ect.) from 175 main to 168 and 50 Pilot.
So a small change required more fuel and as I progressed, for the most part, my jet size went down.