Hope you have a great trip. I went to school up in Ithaca and the weather is great this time of the year in upstate NY. I didn't have a bike at the time, but I would love to go back up there just to ride in the future.
If you're planning on going through NJ / PA up to Binghamton, Rt 11 that runs up parallel to 81 from Scranton, PA is a great detour. Rt 89 next to Cayuga lake is also very scenic. I usually avoid taking 17 from NYC to Binghamton unless you like talking to multiple with state troopers for going 56 in a 55 zone. Also, going through the Grand Central -> Triboro Bridge -> Harlem River Drive -> GWB is usually faster for getting out of the city than taking the Cross Bronx to the GWB.
Try out Dinosaur BBQ in Syracuse and the Buffalo Wild Wings in Rochester near RIT and Anchor Bar in Buffalo. The ones upstate are much better than the ones in NYC. Don't forget to leave room in your luggage for the duty free shops at the border.
2012 Yamaha Super Tenere
2001 Honda Blackbird
2007 Honda 919
49/50 visited on two wheels. 1 more to go!